ED Medication Comparison Calculator
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Based on UK pricing and clinical data from the article.
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When it comes to treating erectile dysfunction (ED), Tadarise has become a popular choice in the UK, but many men wonder how it really measures up against other options on the market. This guide breaks down the science, the price tags, and the real‑world experiences so you can decide which pill fits your lifestyle and budget.
Quick Takeaways
- Tadarise contains 20mg of tadalafil, offering up to 36hours of activity.
- Viagra (sildenafil) works faster but lasts only about 4‑6hours.
- Cialis is the brand name for tadalafil; Tadarise is a UK‑specific formulation with a lower cost per tablet.
- Avanafil (Stendra) provides the quickest onset (15‑30minutes) but is the most expensive.
- Non‑prescription supplements like L‑arginine can help mild cases but lack the reliability of FDA‑approved pills.
How Tadarise Works
Tadarise is a tablet that contains 20mg of tadalafil, a phosphodiesterase‑5 (PDE5) inhibitor. By blocking the PDE5 enzyme, it helps blood vessels in the penis relax, allowing a natural erection when sexual stimulation occurs. Its long half‑life means the effect can last up to 36hours, giving you a flexible window for intimacy.

Key Alternatives at a Glance
Below are the most widely prescribed PDE5 inhibitors and a couple of popular non‑prescription routes.
- Cialis - the branded version of tadalafil, usually priced higher than Tadarise.
- Viagra - contains sildenafil, works in 30‑60 minutes, lasts 4‑6 hours.
- Levitra - contains vardenafil, similar onset to Viagra, slightly longer duration.
- Stendra - brand of avanafil, fastest onset (15‑30 minutes) but costs more.
- Generic Tadalafil - same active ingredient as Tadarise, often sold in bulk by pharmacies.
- L‑arginine - an amino‑acid supplement that can improve blood flow in mild ED cases.
- Erectile Dysfunction - the medical condition being treated; affects about 30% of men over 40 in the UK.
Side‑by‑Side Comparison
Attribute | Tadarise (20mg) | Cialis (20mg) | Viagra (100mg) | Levitra (20mg) | Stendra (100mg) | Generic Tadalafil (20mg) | L‑arginine (500mg) |
---|---|---|---|---|---|---|---|
Onset | 30‑60min | 30‑60min | 30‑60min | 30‑60min | 15‑30min | 30‑60min | 30‑90min (variable) |
Duration | Up to 36hr | Up to 36hr | 4‑6hr | 4‑6hr | 6‑12hr | Up to 36hr | 1‑2hr (if effective) |
Common Side‑effects | Headache, indigestion, back pain | Headache, flushing, muscle aches | Flushing, visual changes, headache | Flushing, dizziness, headache | Headache, nasal congestion | Same as Tadarise | Gastrointestinal upset, low blood pressure (rare) |
Average UK Cost per Tablet | £0.45 (online pharmacy) | £0.80 (brand) | £0.70 (brand) | £0.85 (brand) | £1.20 (brand) | £0.30 (bulk generic) | £0.10 (over‑the‑counter) |
Prescription Needed? | Yes (UK) | Yes | Yes | Yes | Yes | Yes (often via GP) | No |
Pros and Cons of Each Option
Below we unpack the strengths and weaknesses of each pill, helping you match the medication to your lifestyle.
Tadarise (Tadalafil)
Pros: Long window of effectiveness, lower price than brand‑name Cialis, solid safety profile for most healthy men. Cons: Takes up to an hour to work, may cause back pain for some users, requires a prescription.
Cialis (Brand Tadalafil)
Pros: Trusted brand reputation, same pharmacology as Tadarise, available in daily low‑dose form for spontaneous intimacy. Cons: Higher cost per tablet, occasional reports of visual disturbances.
Viagra (Sildenafil)
Pros: Fastest onset among the older drugs (30 minutes), extensive clinical data, widely covered by NHS for certain cases. Cons: Shorter duration means you need to plan timing, may cause facial flushing and visual color shifts.
Levitra (Vardenafil)
Pros: Similar onset to Viagra, slightly less impact on vision, good alternative when sildenafil isn’t tolerated. Cons: Same short‑duration window, can interact with some antihypertensives.
Stendra (Avanafil)
Pros: The quickest onset (15‑30minutes) and relatively mild side‑effects. Cons: Premium price, limited availability in the UK compared to other PDE5 inhibitors.
Generic Tadalafil
Pros: Cheapest way to get the same molecule, often available in 10mg, 20mg, or 40mg packs. Cons: Quality can vary between manufacturers; always buy from reputable pharmacies.
L‑arginine (Supplement)
Pros: No prescription needed, may improve mild ED by boosting nitric oxide levels. Cons: Effects are modest at best; not a substitute for PDE5 inhibitors in moderate‑to‑severe cases.

Factors to Consider When Choosing
- Onset vs. spontaneity: If you need a pill that works right away, avanafil or sildenafil are better fits. For a relaxed weekend window, tadalafil‑based options shine.
- Duration of activity: Longer‑acting drugs let you stay “ready” without re‑dosing, useful for travel or unpredictable schedules.
- Cost and insurance coverage: Generic tadalafil and bulk purchases dramatically cut out‑of‑pocket spend.
- Side‑effect tolerance: Men with a history of back pain may lean toward sildenafil; those prone to flushing may choose tadalafil.
- Health interactions: Nitrates, certain alpha‑blockers, and severe heart disease rule out PDE5 inhibitors. Always discuss with a GP.
- Frequency of use: Daily low‑dose tadalafil (2.5mg) is an option for men who want continuous readiness, whereas on‑demand pills suit occasional use.
Practical Tips & Common Pitfalls
- Take the pill with water, not a heavy meal. Fatty foods can delay absorption, especially for sildenafil.
- Avoid alcohol excess; it can blunt the erection and increase side‑effects.
- Start with the lowest effective dose. For tadalafil, 10mg works for many; only increase to 20mg if needed.
- Never combine PDE5 inhibitors with nitrates (e.g., nitroglycerin) - the risk of a dangerous blood‑pressure drop is real.
- If you experience persistent headache or back pain, try a lower dose or switch to a different molecule.
Frequently Asked Questions
Can I buy Tadarise without a prescription in the UK?
No. Tadarise contains tadalafil, which is a prescription‑only medication in the UK. You need a GP or tele‑health prescription to obtain it legally.
Is Tadarise the same as Cialis?
Chemically they are identical - both contain tadalafil. The difference lies in branding and price; Tadarise is a UK‑specific generic brand that’s generally cheaper than the branded Cialis.
How does the effectiveness of Tadarise compare to Viagra?
Both work for the majority of men with mild‑to‑moderate ED. Viagra acts faster (30‑60 minutes) but its effect ends after 4‑6 hours. Tadarise takes a bit longer to kick in but can last up to 36 hours, giving a larger time window.
Are there any foods or drinks that should be avoided with Tadarise?
Heavy, fatty meals can delay absorption, especially for sildenafil‑based pills, but the effect is modest with tadalafil. Alcohol in excess should be limited because it can reduce erection quality and increase side‑effects.
Can I use Tadarise daily at a lower dose?
Yes. A daily low‑dose regimen (2.5mg or 5mg) is approved for men who want continuous readiness. It’s a different prescription from the on‑demand 10mg/20mg tablets.
Is L‑arginine a viable replacement for prescription ED pills?
L‑arginine may help in very mild cases by boosting nitric oxide, but it does not provide the reliable erection response that PDE5 inhibitors deliver for moderate or severe ED.
Choosing the right ED medication is a personal decision that hinges on timing, cost, side‑effect tolerance, and medical history. By comparing Tadarise with its main rivals - Cialis, Viagra, Levitra, Stendra, generic tadalafil, and even supplements - you now have a clearer picture of what each option brings to the table. Always discuss with a healthcare professional before starting or switching any medication.